Painless Re2O in Gangnam, Seoul | RESUM Plastic Surgery
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Painless Elravie Re2O

Painless Re2O

PAINLESS ELRAVIE RE2O

A Re2O skin booster with collagen-stimulating ingredients that helps improve skin elasticity and texture.

Method
30-45 minutes
Anesthesia
Recovery
Topical or local anesthesia · Daily activities right after
Summary Painless Re2O is a 4th-generation skin booster that restores the dermis itself by directly replenishing dermal structural proteins such as collagen, elastin, and GAGs, and its mechanism of action differs from that of PN and PDLLA. It is performed at RESUM Plastic Surgery in Gangnam, Seoul (Apgujeong). Medical Review Medical Review: Won-Suk Kook,Jin-Young Kim
Last updated: 2026-08-10

Why Lisoom

Overview Skin Booster with Collagen-Stimulating Ingredients

Re2O (Elravie Re2O) is a dermal booster that directly replenishes human-derived ECM (extracellular matrix) components.
Factors that trigger immune reactions are removed from human acellular dermal matrix (hADM), while dermal structural proteins such as collagen, elastin, and glycosaminoglycans (GAGs) are left intact and injected into the dermis, so its mechanism of action differs from that of PN (Rejuran) or PDLLA (Juvelook).

As an ECM-based booster that replenishes the dermal structure itself, its results settle in gradually, and it is usually given as a series of 3-4 sessions spaced about 1 month apart. Results vary between individuals.

DESIGN PRINCIPLE

Methods
How Painless Re2O Works

Extracellular Matrix SUTURE guide image

SutureExtracellular Matrix

It directly replenishes the structural proteins of the dermis, including 89% collagen + elastin + glycosaminoglycans (GAGs). Rather than stimulating collagen production as PN or PDLLA do, it fills in the structure itself, so the mechanism of action is different.

89% Collagen Elastin GAG
Multilayer Dermis HYBRID guide image

HybridMultilayer Dermis

The product is distributed densely across the entire face through multilayer injection into the dermis. Rather than concentrating on one area, wide-area distribution is used to fill in the dermal structure. The distribution sites are adjusted according to the area and goal.

Multilayer Dermis Wide-Area Distribution Dense Injection
Pain Reduction PARTIAL guide image

PartialPain Reduction

To reduce pain during treatment, a topical numbing cream, local anesthesia, a vibration device, and other measures are used together. We explain that the term "painless" does not mean there is no pain at all but that the treatment is less painful than a typical booster treatment.

Topical Anesthesia With Local Anesthesia Pain Reduction
Series Treatment INCISION guide image

IncisionSeries Treatment

For a first course, a series of 3-4 sessions spaced about one month apart is recommended. A major change is difficult to expect from 1 session; the recovery of dermal structure settles in as sessions accumulate. Subsequent maintenance treatments are decided during the consultation according to each person's skin condition.

1-Month Intervals Series of 3-4 Sessions Step-by-Step Buildup

OUR PRINCIPLE

Core Values
The Principles RESUM Keeps

Re2O is a treatment that directly replenishes the dermal structure. We explain the mechanism of action and the expected course of results in advance and proceed only when it is suitable.

Right Indication

Right Indication

Indication Assessment

During the consultation, we distinguish skin conditions that are suited to Re2O from those that are not. It is often recommended for those who need recovery of dermal structure; when immediate volume enhancement is the priority, we suggest a cross-linked filler.

Honest Comfort

Honest Comfort

Honest Guidance

We explain honestly during the consultation that the term "painless" does not mean there is no pain at all but that the treatment is less painful than a typical booster treatment. Topical anesthesia and a vibration device reduce the discomfort, but the injections themselves still cause some.

Right Combination

Right Combination

Combination First

Re2O is meaningful on its own, but its role in supporting dermal recovery stands out when combined with other treatments (laser, fillers, Botox). The order and combination of treatments are decided during the consultation according to the patient's skin condition and schedule.

POINT 03 Features

Painless Re2O Features

Directly Replenishing ECM Structural Proteins

Directly Replenishing ECM Structural Proteins

Re2O replenishes the dermis with ECM components from human-derived acellular dermal matrix (hADM), from which the factors that trigger immune reactions have been removed while the dermal structural proteins such as collagen, elastin, and GAGs are left intact. Unlike PN and PDLLA, which stimulate collagen production, this approach fills in the structure itself, so the mechanism of action is distinct. · Replenishes human-derived ECM (hADM) components · Structural proteins such as collagen, elastin, and GAGs · Replenishes the structure rather than stimulating it · A mechanism of action different from PN and PDLLA

Multilayer Dermal Injection & Pain Reduction

Multilayer Dermal Injection & Pain Reduction

Re2O is distributed densely in multiple layers into the dermis, and the recovery of dermal structure settles in as it accumulates, usually over a series of 3-4 sessions spaced about 1 month apart. To reduce pain during treatment, a topical numbing cream, local anesthesia, a vibration device, and other measures are used together. · Multilayer, wide-area distribution in the dermis · Usually a series of 3-4 sessions about 1 month apart · Discomfort eased with topical and local anesthesia and vibration · Also used to support recovery from other treatments

NOTICE

Precautions
Aftercare & Precautions

N · 01 Unlike PN and PDLLA, which stimulate collagen production, Re2O directly replenishes human-derived ECM (collagen, elastin, GAGs), so it is advisable to choose it with the understanding that it is a booster with a different mechanism of action.
N · 02 Because it uses ECM components from human acellular dermal matrix (hADM) with the factors that trigger immune reactions removed, please tell us at the consultation stage about any past treatments and any allergy or immune-related matters.
N · 03 Some sense of hydration may be seen right after treatment, but the recovery of dermal structure settles in gradually, so rather than assuming an immediate change, we observe the progress over time.
N · 04 A topical numbing cream, local anesthesia, and a vibration device are used together to reduce pain, but this does not mean there is no pain at all, and the degree of discomfort varies between individuals.
N · 05 For a first course, a series of 3-4 sessions spaced about 1 month apart is recommended, and we explain in advance that the treatment proceeds cumulatively rather than completing structural replenishment in 1 session.
N · 06 Temporary redness or raised bumps may appear after multilayer distributed injection into the dermis, and when it is combined with other treatments, the order and intervals are adjusted together during the consultation.

PROCEDURE DATA

Summary
Treatment Overview

Procedure

Treatment Overview

Treatment time
30-45 minutes
Anesthesia
Topical Anesthesia
Treatment interval
3 sessions, 2-3 months apart
Duration
About 12 months

FOR WHOM

Candidates

Consider a Consultation If

05 Recommended Cases

01 Those who want an approach that directly replenishes the dermal structural proteins themselves rather than stimulating collagen
02 Those looking for an ECM-based booster with a mechanism different from that of PN (Rejuran) or PDLLA (Juvelook)
03 Those who want to gradually restore the dermal structure and the environment for elasticity rather than gain immediate volume
04 Those who want to start a dermal booster with a protocol designed to reduce pain
05 Those looking for a booster to support dermal recovery during recovery from laser, fillers, or Botox
Jin-Young Kim · M.D. - RESUM Plastic Surgery Clinic

Doctor's Note

Re2O is a treatment that directly replenishes the structural proteins of the dermis, so its mechanism of action differs from that of PN or PDLLA. We explain honestly during the consultation that the term "painless" does not mean there is no pain at all but that there is less pain. Satisfaction with the results is higher when patients understand in advance that this is a treatment that builds up over a series.

Jin-Young Kim · M.D.

Dr. Jin-Young Kim, Director

PROCEDURE FLOW

Process
Treatment Process

01

PHASE I

Assessing the Need for Dermal Recovery

We look at skin thickness, elasticity, and the degree to which recovery of dermal structure is needed, and decide during the consultation whether Re2O is suitable.

CARE

02

PHASE II

Preparing to Reduce Pain

A topical numbing cream, local anesthesia, and a vibration device are applied together to reduce pain during treatment.

STEP

03

PHASE III

Multilayer Dermal ECM Replenishment

ECM components containing collagen, elastin, and GAGs are distributed densely in the dermis to replenish the structure itself.

STEP

04

PHASE IV

Building a Monthly Series

Structural recovery is built up over 3-4 sessions spaced about 1 month apart, and the timing of later maintenance is decided according to skin condition.

STEP

FREQUENTLY ASKED

FAQ
Frequently Asked Questions

We have compiled the questions patients ask most often before a consultation.

Re2O is a booster that restores the dermal structure itself by directly replenishing human-derived ECM (extracellular matrix) components (89% collagen + elastin + GAGs, etc.). Its mechanism of action differs from that of PN (Rejuran) or PDLLA (Juvelook), and it is classed as a 4th-generation booster that fills in the dermal structure itself.
It is because a topical numbing cream, local anesthesia, a vibration device, and other measures are used together to reduce pain during treatment, making it less uncomfortable than a typical booster treatment. However, it does not mean there is no pain at all, and we explain honestly during the consultation that the injections themselves cause some discomfort.
Some hydrating effect is seen right after treatment, while the recovery of dermal structure settles in gradually. Changes begin to be noticed 2-4 weeks after 1 session, and stable results settle in after a series of 3-4 sessions is completed. The course of results differs from that of treatments expected to produce immediate changes.
You can return to daily activities the same day. Temporary swelling, bruising, and erythema may appear, but most subside naturally within 3-5 days. It is advisable to keep your schedule flexible for the first 2-3 days.
Temporary redness, swelling, bruising, and erythema may occur, and most settle within 3-5 days. In rare cases, nodules or hypersensitivity reactions have been reported. To lower the risk, suitability is assessed at a consultation beforehand.
The estimate depends on the product used, the treatment area, and the number of sessions in the series. During your visit, we assess your skin condition and goals, decide on the product and number of sessions, and then provide an estimate.

RESUM Plastic Surgery Clinic Location

#601, 6F, 842 Nonhyeon-ro, Gangnam-gu, Seoul

6F #601, 599-4 Sinsa-dong, Gangnam-gu, Seoul

HOURS

Weekdays
10:00 ~ 20:00
Saturday
10:00 ~ 17:00
Lunch Break
1:00 PM - 2:00 PM

(No lunch break on weekends and public holidays) *Dr. Won-Suk Kook is not available on the 1st and 3rd Saturdays of each month.

Parking Information Parking is available in the building. 1 hour of free parking

Subway 5-minute walk from Exit 3 of Apgujeong Station on Line 3 (right next to the 14-story CGV building at Exit 3)

RESUM Plastic Surgery Clinic CEO Won-Suk Kook Business No. 733-11-02929 Phone 02-3445-7770