Painless Rejuran in Gangnam, Seoul | RESUM Plastic Surgery
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Painless Rejuran

Painless Rejuran

PAINLESS REJURAN

A Rejuran skin booster that uses PN to help support the skin's recovery environment and improve texture.

Method
30-45 minutes
Anesthesia
Recovery
Topical anesthesia · Daily activities right after
Summary Painless Rejuran is a regenerative treatment that uses PN derived from salmon DNA to stimulate fibroblasts and restore dermal thickness and skin texture, with effects appearing gradually over repeated sessions. It is performed at RESUM Plastic Surgery in Gangnam, Seoul (Apgujeong). Medical Review Medical Review: Won-Suk Kook,Jin-Young Kim
Last updated: 2026-08-10

Why Lisoom

Overview PN-Based Care for the Skin's Recovery Environment
and Texture, Step by Step

Rejuran is a dermal regeneration booster whose main ingredient is polynucleotide (PN) extracted from salmon DNA.

PN is structurally similar to human DNA and tends to be highly biocompatible. When injected into the dermis, it activates fibroblasts, stimulating the recovery of dermal thickness and the production of collagen and elastin.
It is not a treatment that adds immediate volume but one that raises the dermis's own capacity to recover, so results appear gradually. It is usually given as a series of 3-4 sessions spaced 2-4 weeks apart. Results vary between individuals.

DESIGN PRINCIPLE

Methods
How Painless Rejuran Works

Polynucleotide SUTURE guide image

SuturePolynucleotide

The main ingredient is polynucleotide (PN) extracted from salmon DNA. When injected into the dermis, it activates fibroblasts, stimulating the recovery of dermal thickness and the production of collagen and elastin. It is structurally similar to human DNA and therefore highly biocompatible.

Salmon DNA fibroblast Dermal Thickness
Multilayer Dermis HYBRID guide image

HybridMultilayer Dermis

The product is distributed densely across the entire face through multilayer injection into the dermis. Rather than concentrating on one area, wide-area distribution is used to raise the dermis's own capacity to recover. The distribution sites are adjusted according to the area and goal.

Multilayer Dermis Wide-Area Distribution Dense Injection
Series Treatment PARTIAL guide image

PartialSeries Treatment

A series of 3-4 sessions spaced 2-4 weeks apart is the most common protocol. A major change is difficult to expect from 1 session; the recovery of dermal thickness settles in as sessions accumulate. Subsequent maintenance treatments are decided during the consultation according to each person's skin condition.

2-4 Week Intervals Series of 3-4 Sessions Step-by-Step Buildup
Product Selection INCISION guide image

IncisionProduct Selection

Different products suit different areas and goals, such as Rejuran Healer (skin texture, fine lines), Rejuran i (eye area), and Rejuran HB (enhanced hydration). The suitable product is decided after the patient's skin condition and goals are assessed during the consultation.

Healer i (Eye) HB

OUR PRINCIPLE

Core Values
The Principles RESUM Keeps

Rejuran is not a treatment that delivers an immediate effect but one that promotes dermal recovery. Results settle in as the series accumulates.

Right Indication

Right Indication

Indication Assessment

During the consultation, we distinguish skin conditions that are suited to Rejuran from those that are not. It is often recommended for those who need improvement in pores and fine lines and recovery of dermal thickness; when immediate volume enhancement is needed, we suggest other treatments.

Honest Timing

Honest Timing

Series Guidance

We explain in advance that a major change is difficult to expect from 1 session. A series of 3-4 sessions spaced 2-4 weeks apart is the standard, and we make sure patients understand beforehand that this is a treatment whose results settle in gradually.

Right Combination

Right Combination

Combination First

Rejuran is meaningful on its own, but its role in supporting recovery stands out when combined with other treatments (laser, Botox, fillers). The order and combination of treatments are decided during the consultation according to the patient's skin condition and schedule.

POINT 03 Features

Painless Rejuran Features

How Salmon DNA-Derived PN Works

How Salmon DNA-Derived PN Works

The main ingredient of Rejuran is polynucleotide (PN) extracted and purified from salmon DNA. PN is structurally similar to human DNA and tends to be highly biocompatible. When injected into the dermis, it stimulates fibroblasts, inducing the recovery of dermal thickness and the production of collagen and elastin. It is not a filling treatment but one that improves the recovery environment. · Polynucleotide (PN) derived from salmon DNA · Fibroblast activation · Stimulates recovery of dermal thickness and collagen production · Gradual results rather than immediate volume

Multilayer Dermal Injection & Series

Multilayer Dermal Injection & Series

Rejuran is distributed densely in multiple layers into the dermis across the entire face. The most common protocol is a series of 3-4 sessions spaced 2-4 weeks apart, with dermal recovery settling in as sessions accumulate. Because the number of injections is high and the treatment tends to be uncomfortable, a topical numbing cream and other measures are used to ease it. There are products for different areas and goals, such as Rejuran Healer, i, and HB. · Multilayer, wide-area distribution in the dermis · Usually a series of 3-4 sessions at 2-4 week intervals · Topical anesthesia generally used to reduce pain · Product chosen by area, such as Healer, i, or HB

POINT 04 Benefits

Will I See Results Right After One Rejuran Session?

First, it is a gradual recovery treatment, not an immediate volume treatment.

First, it is a gradual recovery treatment, not an immediate volume treatment.

Rejuran is not a filling treatment like fillers but one that stimulates dermal recovery, so results appear slowly. Changes usually begin to be noticed 2-4 weeks after 1 session, and because this varies between individuals, we explain the expected course in advance.

Second, results settle in only as the series accumulates.

Second, results settle in only as the series accumulates.

Some change may be felt after 1 session alone, but the recovery of dermal thickness tends to settle in only as the series accumulates. We usually recommend 3-4 sessions spaced 2-4 weeks apart, and the timing of later maintenance is explained during the consultation according to each person's skin condition.

Third, please tell us in advance about any history of fish allergy.

Third, please tell us in advance about any history of fish allergy.

Rejuran is made from salmon DNA, so if you have a history of fish protein allergy, please be sure to tell us at the consultation stage. Depending on the severity of the allergy, we assess together during the consultation whether the treatment is suitable and whether an alternative booster is appropriate.

NOTICE

Precautions
Aftercare & Precautions

N · 01 Rejuran is made from polynucleotide (PN) extracted from salmon DNA, so if you have a history of fish protein allergy, please be sure to tell us at the consultation stage.
N · 02 PN is not an ingredient that adds volume; it works by stimulating fibroblasts to promote the recovery of dermal thickness, so it shows as gradual results rather than an immediate change.
N · 03 Because the product is injected densely in multiple layers into the dermis across the entire face, the number of injections tends to be high. Topical anesthesia is used to reduce pain, but some discomfort may still occur during treatment.
N · 04 The most common course is a series of 3-4 sessions spaced 2-4 weeks apart. Rather than a major change from 1 session alone, the recovery of dermal thickness settles in as sessions accumulate.
N · 05 The suitable product, such as Rejuran Healer, i, or HB, differs by area and goal, so specific goals such as the eye area, texture, or hydration are set during the consultation.
N · 06 Temporary redness or raised bumps may appear at the injection sites. How the skin settles and the timing of the next session vary between individuals and are explained during the consultation.

PROCEDURE DATA

Summary
Treatment Overview

Procedure

Treatment Overview

Treatment time
30-45 minutes
Anesthesia
Topical Anesthesia
Treatment interval
3 sessions, 4 weeks apart
Duration
About 6-12 months

FOR WHOM

Candidates

Consider a Consultation If

05 Recommended Cases

01 Those who want to build up the thickness and resilience of the dermis itself step by step rather than fill as with fillers
02 Those who want to start with a Rejuran product chosen in consultation to fit their goal, such as fine lines and skin texture, the eye area, or hydration
03 Those who can accept gradual results over a series spaced 2-4 weeks apart rather than an immediate change
04 Those looking for a booster to support dermal recovery during recovery from laser, Botox, or fillers
05 Those who want to have any history of fish protein allergy checked in consultation before starting
Jin-Young Kim · M.D. - RESUM Plastic Surgery Clinic

Doctor's Note

Rejuran is a treatment that promotes dermal recovery, so a major change is difficult to expect from 1 session, and results settle in as the series accumulates. During the consultation, we look at the patient's skin condition together with any combination with other treatments and decide on suitability and the number of sessions. When immediate volume enhancement is needed, we honestly suggest other treatments.

Jin-Young Kim · M.D.

Dr. Jin-Young Kim, Director

PROCEDURE FLOW

Process
Treatment Process

01

PHASE I

Dermal Assessment

We look at thickness, fine lines, the eye area, and hydration, and decide during the consultation whether Rejuran is suitable and which product and areas fit.

STEP

02

PHASE II

Topical Anesthesia

Because the number of injections tends to be high, a topical numbing cream is applied to reduce pain, and then the distribution plan is checked.

ANESTHESIA

03

PHASE III

Multilayer Dermal PN Injection

Polynucleotide is distributed densely and widely in the dermis across the entire face to stimulate the recovery environment.

STEP

04

PHASE IV

Building the Series & Maintenance

The recovery of dermal thickness is built up over 3-4 sessions spaced 2-4 weeks apart, and the timing of later maintenance is decided according to skin condition.

STEP

FREQUENTLY ASKED

FAQ
Frequently Asked Questions

We have compiled the questions patients ask most often before a consultation.

Rejuran is a dermal regeneration booster whose main ingredient is polynucleotide (PN) extracted from salmon DNA. PN is structurally similar to human DNA and therefore highly biocompatible. When injected into the dermis, it activates fibroblasts, stimulating the recovery of dermal thickness and the production of collagen and elastin. It is not a treatment that adds immediate volume but one that promotes dermal recovery.
The lineup includes Rejuran Healer (skin texture, fine lines, pores), Rejuran i (fine lines around the eyes), Rejuran HB (combined with hyaluronic acid for enhanced hydration), and Rejuran i (skin texture, glow). Different products suit different areas and goals, and the product that fits the patient's skin condition is decided during the consultation.
Rejuran works by stimulating dermal recovery, so results appear gradually. Changes begin to be noticed 2-4 weeks after 1 session, and stable results settle in after a series of 3-4 sessions is completed. It works differently from treatments that are expected to produce immediate changes.
You can return to daily activities the same day. Redness and swelling around the injection marks settle within a few days, and bruising, if any, may last about 1 week. It is advisable to keep your schedule flexible for the first 2-3 days.
Temporary redness, needle marks, swelling, and bruising may occur and settle within a few days. In rare cases, nodules or hypersensitivity reactions have been reported. To lower the risk, suitability is assessed at a consultation beforehand.
The estimate depends on the product used, the treatment area, and the number of sessions in the series. During your visit, we assess your skin condition and goals, decide on the product and number of sessions, and then provide an estimate.

RESUM Plastic Surgery Clinic Location

#601, 6F, 842 Nonhyeon-ro, Gangnam-gu, Seoul

6F #601, 599-4 Sinsa-dong, Gangnam-gu, Seoul

HOURS

Weekdays
10:00 ~ 20:00
Saturday
10:00 ~ 17:00
Lunch Break
1:00 PM - 2:00 PM

(No lunch break on weekends and public holidays) *Dr. Won-Suk Kook is not available on the 1st and 3rd Saturdays of each month.

Parking Information Parking is available in the building. 1 hour of free parking

Subway 5-minute walk from Exit 3 of Apgujeong Station on Line 3 (right next to the 14-story CGV building at Exit 3)

RESUM Plastic Surgery Clinic CEO Won-Suk Kook Business No. 733-11-02929 Phone 02-3445-7770